 |
Table 2
Ranking of probe clusters within the consensus sites1
Protein
|
Consensus Site
|
Probe
|
Acetone
|
Urea
|
DMSO
|
Isopropanol
|
T-Butanol
|
Phenol
|
|
|
1EBG
|
1
|
1 (0.26)
|
1 (0.26)
|
1 (0.48)
|
2 (0.81)
|
1 (0.39)
|
1 (0.36)
|
|
|
2
|
-
|
3 (10.11)
|
2 (9.82)
|
3 (9.14)
|
2 (9.10)
|
2 (11.10)
|
|
|
3
|
4 (18.65)
|
-
|
4 (16.38)
|
-
|
4 (16.68)
|
4 (17.65)
|
|
|
4
|
2 (14.38)
|
4 (14.38)
|
3 (14.58)
|
-
|
-
|
5 (15.26)
|
|
|
5
|
3 (25.17)
|
-
|
-
|
5 (24.52)
|
-
|
3 (24.23)
|
|
|
6
|
5 (9.00)
|
-
|
5 (8.08)
|
4 (7.44)
|
-
|
-
|
|
|
|
1RNT
|
1
|
2 (0.51)
|
4 (0.35)
|
1 (0.37)
|
5 (0.48)
|
1 (0.40)
|
1 (0.21)
|
|
|
2
|
3 (15.92)
|
5 (14.21)
|
5 (15.04)
|
-
|
5 (15.34)
|
5 (14.28)
|
|
|
3
|
-
|
1 (10.61),
2 (10.54)
|
2 (11.76)
|
4 (12.38)
|
-
|
2 (12.31)
|
|
|
4
|
-
|
-
|
3 (10.24)
|
1 (12.02)
|
3 (10.29)
|
4 (11.65)
|
|
|
5
|
-
|
3 (14.24)
|
-
|
2 (15.92)
|
-
|
3 (14.42)
|
|
|
6
|
-
|
-
|
4 (0.74)
|
-
|
2(0.65)
|
-
|
|
|
|
2YPI
|
1
|
1 (0.49)
|
2 (0.76)
|
1 (0.46)
|
1 (0.70)
|
-
|
1 (0.26)
|
|
|
2
|
2 (20.14)
|
3 (19.35)
|
3 (20.75)
|
4 (20.17)
|
-
|
-
|
|
|
3
|
-
|
-
|
-
|
3 (6.74)
|
1 (5.71)
|
2 (5.52)
|
|
|
4
|
-
|
-
|
2 (14.48)
|
-
|
-
|
4 (16.14)
|
|
|
5
|
3 (12.80)
|
-
|
-
|
2 (12.53)
|
-
|
-
|
|
|
|
1TNG
|
1
|
1 (0.30)
|
4 (0.65)
|
1 (0.17)
|
1 (0.60)
|
1 (0.32)
|
1 (0.50)
|
|
|
2
|
2 (17.46),
3 (17.97)
|
3 (18.01)
|
2 (17.44)
|
2 (16.92)
|
-
|
4 (17.18)
|
|
|
3
|
4 (15.30)
|
-
|
3 (14.91)
|
3 (15.27)
|
2 (15.89)
|
2 (15.72)
|
|
|
4
|
-
|
-
|
4 (16.54)
|
5 (17.61)
|
4 (17.85)
|
5 (15.94)
|
|
|
|
1FBC
|
1
|
1 (1.41)
|
1 (0.43)
|
2 (0.59)
|
4 (0.80)
|
4 (0.52),
2 (0.61)
|
3 (0.92)
|
|
|
2
|
5 (1.72)
|
3 (1.28)
|
4 (0.44)
|
1 (1.18)
|
-
|
2 (0.87)
|
|
|
3
|
2 (11.86)
|
2 (10.06)
|
5 (11.76)
|
2 (9.90)
|
5 (11.33)
|
1 (9.64)
|
|
|
4
|
-
|
-
|
1 (22.85)
|
-
|
-
|
4 (23.46)
|
|
|
|
2DHC
|
1
|
1 (0.62)
|
1 (0.56)
|
-
|
1 (0.78)
|
-
|
-
|
|
|
2
|
3 (9.84)
|
3 (7.80)
|
4 (9.71)
|
3 (8.12)
|
1 (9.87)
|
2 (8.02)
|
|
|
3
|
2 (10.81)
|
4 (10.32)
|
2 (10.23),
5 (10.36)
|
4 (9.81)
|
3 (10.49)
|
5 (10.12)
|
|
|
4
|
-
|
2 (11.40)
|
1 (13.18)
|
5 (12.62)
|
-
|
-
|
|
|
5
|
-
|
-
|
3 (12.23)
|
-
|
-
|
1 (11.37)
|
1. The distance of each cluster center from the ligand in the x-ray
structure of the enzyme is shown in parenthesis.
|