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Table 2

Ranking of probe clusters within the consensus sites1

Protein
Consensus Site
Probe
Acetone
Urea
DMSO
Isopropanol
T-Butanol
Phenol

1EBG

1

1 (0.26)

1 (0.26)

1 (0.48)

2 (0.81)

1 (0.39)

1 (0.36)

2

-

3 (10.11)

2 (9.82)

3 (9.14)

2 (9.10)

2 (11.10)

3

4 (18.65)

-

4 (16.38)

-

4 (16.68)

4 (17.65)

4

2 (14.38)

4 (14.38)

3 (14.58)

-

-

5 (15.26)

5

3 (25.17)

-

-

5 (24.52)

-

3 (24.23)

6

5 (9.00)

-

5 (8.08)

4 (7.44)

-

-

 

1RNT

1

2 (0.51)

4 (0.35)

1 (0.37)

5 (0.48)

1 (0.40)

1 (0.21)

2

3 (15.92)

5 (14.21)

5 (15.04)

-

5 (15.34)

5 (14.28)

3

-

1 (10.61),

2 (10.54)

2 (11.76)

4 (12.38)

-

2 (12.31)

4

-

-

3 (10.24)

1 (12.02)

3 (10.29)

4 (11.65)

5

-

3 (14.24)

-

2 (15.92)

-

3 (14.42)

6

-

-

4 (0.74)

-

2(0.65)

-

 

2YPI

1

1 (0.49)

2 (0.76)

1 (0.46)

1 (0.70)

-

1 (0.26)

2

2 (20.14)

3 (19.35)

3 (20.75)

4 (20.17)

-

-

3

-

-

-

3 (6.74)

1 (5.71)

2 (5.52)

4

-

-

2 (14.48)

-

-

4 (16.14)

5

3 (12.80)

-

-

2 (12.53)

-

-

 

1TNG

1

1 (0.30)

4 (0.65)

1 (0.17)

1 (0.60)

1 (0.32)

1 (0.50)

2

2 (17.46),

3 (17.97)

3 (18.01)

2 (17.44)

2 (16.92)

-

4 (17.18)

3

4 (15.30)

-

3 (14.91)

3 (15.27)

2 (15.89)

2 (15.72)

4

-

-

4 (16.54)

5 (17.61)

4 (17.85)

5 (15.94)

 

1FBC

1

1 (1.41)

1 (0.43)

2 (0.59)

4 (0.80)

4 (0.52),

2 (0.61)

3 (0.92)

2

5 (1.72)

3 (1.28)

4 (0.44)

1 (1.18)

-

2 (0.87)

3

2 (11.86)

2 (10.06)

5 (11.76)

2 (9.90)

5 (11.33)

1 (9.64)

4

-

-

1 (22.85)

-

-

4 (23.46)

 

2DHC

1

1 (0.62)

1 (0.56)

-

1 (0.78)

-

-

2

3 (9.84)

3 (7.80)

4 (9.71)

3 (8.12)

1 (9.87)

2 (8.02)

3

2 (10.81)

4 (10.32)

2 (10.23),

5 (10.36)

4 (9.81)

3 (10.49)

5 (10.12)

4

-

2 (11.40)

1 (13.18)

5 (12.62)

-

-

5

-

-

3 (12.23)

-

-

1 (11.37)

1. The distance of each cluster center from the ligand in the x-ray structure of the enzyme is shown in parenthesis.