Papers+Conferences

2009
Landon MR, Lieberman RL, Hoang QQ, Ju S, Caaveiro JMM, Orwig SD, Kozakov D, Brenke R, Chuang G-Y, Beglov D et al..  2009.  Detection of ligand binding hot spots on protein surfaces via fragment-based methods: application to DJ-1 and glucocerebrosidase. Journal of Computer-Aided Molecular Design. 23(8):491-500. Download: PDF (574.15 KB)
Brenke R, Kozakov D, Chuang G-Y, Beglov D, Hall DR, Landon MR, Mattos C, Vajda S.  2009.  Fragment-based identification of druggable 'hot spots' of proteins using Fourier domain correlation techniques. Bioinformatics. 25(5):621-627. Download: PDF (412.04 KB)
Beglov D, Brenke R, Chuang G-Y, Hall DR, Landon MR, Ngan CH, Shen Y, Thiel SC, Zerbe B, Kozakov D et al..  2009.  Identification of Druggable Hot Spots on Proteins and in Protein Protein Interfaces. Computational Protein-Protein Interactions.
2008
Landon MR, Amaro RE, Baron R, Ngan CH, Ozonoff D, McCammon AJ, Vajda S.  2008.  Novel Druggable Hot Spots in Avian Influenza Neuraminidase H5N1 Revealed by Computational Solvent Mapping of a Reduced and Representative Receptor Ensemble. Chemical Biology & Drug Design. 71(2):106-116. Download: PDF (845.42 KB)
2007
Landon MR, Lancia, Jr. DR, Yu J, Thiel SC, Vajda S.  2007.  Identification of Hot Spots within Druggable Binding Regions by Computational Solvent Mapping of Proteins. Journal of Medicinal Chemistry. 50(6):1231-1240. Download: PDF (822.44 KB)
2006
Landon MR, Lancia, Jr. DR, Clodfelter KH, Vajda S.  2006.  Clustering of domains of functionally related enzymes in the interaction database PRECISE by the generation of primary sequence patterns. Journal of Molecular Graphics and Modelling. 24(6):426-433. Download: PDF (768.35 KB)
Silberstein M, Landon MR, Wang YE, Perl A, Vajda S.  2006.  Computational methods for functional site identification suggest a substrate access channel in transaldolase. Genome Informatics. 17(1):13-22. Download: PDF (2.84 MB)
Landon MR, Yu J, Thiel SC, Lancia, Jr. DR, Vajda S.  2006.  Identification of "Hot Spots" in Druggable Binding Pockets by Computational Solvent Mapping of Proteins. 232nd National Meeting & Exposition of the American Chemical Society.  Download: PPT (8.62 MB)
2004
Sheu S-H, Lancia, Jr. DR, Clodfelter KH, Landon MR, Vajda S.  2004.  PRECISE: a Database of Predicted and Consensus Interaction Sites in Enzymes. Nucleic Acids Research. 33(Database):D206-D211. Download: PDF (673.78 KB)