Dr. Lawrence Brown

Dr. Lawrence Brown

My research interests are many, but to discuss a representative subset:

  1. I am interested in using alcohols for the purpose of mapping small molecule binding sites on enzymes. We as a lab are interested in using various energetic ensembles, along with docking techniques, to determine a predictive algorithm for establishing putative interaction sites. I'll be focusing on apo-enzymes using analytical continuum electrostatics and global range molecular matching or GRAMM.
  2. Subtle substitutions in the transaldolase enzyme trigger auto-immune disease in humans. I am interested in using computational techniques to determine the specific inter-relationship between structure and dynamics which may lead to this phenotype.
  3. Physical interaction and gene expression data are copious yet the proper interpretation of these results, as well as the establishment of their relevance, has yet to be undertaken. Along with Rakesh Chettier and Sandor Vajda, I'm interested in exploring database development techniques for yeast two-hybrid data and metabolic information.
  4. High-throughput molecular modeling techniques for difficult-to-characterize proteins (i.e. viral proteins) is another pursuit of mine. I'd like to develop better techniques for combining Hidden Markov Models and threading to determine good templates for small microbial proteins.